Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates.

@article{Koliatsos1991HumanNG,
  title={Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates.},
  author={Vassilis E. Koliatsos and Richard Clatterbuck and H J Nauta and B Kn{\"u}sel and Louis E. Burton and Franz Hefti and William C Mobley and Donald L. Price},
  journal={Annals of neurology},
  year={1991},
  volume={30 6},
  pages={831-40}
}
Basal forebrain cholinergic neurons respond to nerve growth factor (NGF), and it has been suggested that the administration of NGF might prevent their degeneration in patients with Alzheimer's disease. One major prerequisite to be fulfilled before the consideration of clinical trials of NGF in patients with Alzheimer's disease is the demonstration that human NGF affects basal forebrain cholinergic neurons in primates. In the present study, we used a recombinant human nerve growth factor (rhNGF… CONTINUE READING

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