Human nephron number: implications for health and disease

  title={Human nephron number: implications for health and disease},
  author={John F. Bertram and Rebecca N. Douglas-Denton and Boucar Diouf and Michael D Hughson and Wendy E Hoy},
  journal={Pediatric Nephrology},
Several studies have shown that total nephron (glomerular) number varies widely in normal human kidneys. Whereas the studies agree that average nephron number is approximately 900,000 to 1 million per kidney, numbers for individual kidneys range from approximately 200,000 to >2.5 million. Several studies have shown loss of glomeruli due to age-related glomerulosclerosis. The rates of loss vary among individuals depending upon blood pressure, diseases affecting the kidney, and other attributes… CONTINUE READING
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