Human neoplastic mesothelial cells express voltage-gated sodium channels involved in cell motility.

@article{Fulgenzi2006HumanNM,
  title={Human neoplastic mesothelial cells express voltage-gated sodium channels involved in cell motility.},
  author={Gianluca Fulgenzi and Laura Graciotti and Monica Faronato and Maria Virginia Soldovieri and Francesco Di Miceli and Salvatore Amoroso and Lucio Annunziato and Ant{\^o}nio Eduardo Proc{\'o}pio and Maurizio Taglialatela},
  journal={The international journal of biochemistry & cell biology},
  year={2006},
  volume={38 7},
  pages={1146-59}
}
Given the pivotal role of ion channels in neoplastic transformation, the aim of the present study has been to assess possible differences in the expression patterns of voltage-gated monovalent cationic (Na(+) and K(+)) currents between normal and neoplastic mesothelial cells (NM, MPM, respectively), and to evaluate the role of specific ion channels in mesothelioma cells proliferation, apoptosis, and motility. To achieve this aim, membrane currents expressed in NM and MPM cells derived from… CONTINUE READING

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