Human natural killer cells suppress the proliferation of B cells.

@article{Commes1990HumanNK,
  title={Human natural killer cells suppress the proliferation of B cells.},
  author={Therese Commes and Gis{\`e}le Clofent and Michel Jourdan and R{\'e}gis Bataille and Bernard Klein},
  journal={Immunology letters},
  year={1990},
  volume={24 1},
  pages={57-61}
}
We have investigated the suppressive effect of human natural killer (NK) cells on autologous B-cell proliferation. Removal of NK cells by anti-NK-cell monoclonal antibodies (CD16, Leu 11b; Leu 7) increased by 2-3-fold the proliferative response of purified B cells activated by anti-mu and B-cell growth factor (BCGF). The inhibitory effect of NK cells was observed using recombinant IL-2 or semi-purified BCGF-I as sources of BCGF. Moreover NK cells, highly purified by centrifugation on a Percoll… CONTINUE READING