Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells.

@article{Chen2014HumanNK,
  title={Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells.},
  author={Qingfeng Chen and Anburaj Amaladoss and Weijian Ye and Min Liu and Sara K. Dummler and Fang Kong and Lan Hiong Wong and Hooi Linn Loo and Eva Loh and Shu Qi Tan and Thiam Chye Tan and Kenneth Tou En Chang and Ming Dao and Subra Suresh and Peter Rainer Preiser and Jianzhu Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 4},
  pages={1479-84}
}
Immunodeficient mouse-human chimeras provide a powerful approach to study host-specific pathogens, such as Plasmodium falciparum that causes human malaria. Supplementation of immunodeficient mice with human RBCs supports infection by human Plasmodium parasites, but these mice lack the human immune system. By combining human RBC supplementation and humanized mice that are optimized for human immune cell reconstitution, we have developed RBC-supplemented, immune cell-optimized humanized (RICH… CONTINUE READING
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Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes

  • K Artavanis-Tsakonas
  • J Immunol
  • 2003
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