Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity.

@article{Voigt2014HumanNK,
  title={Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity.},
  author={Jessica Voigt and Kerstin Huenniger and Maria Bouzani and Ilse D Jacobsen and Dagmar Barz and Bernhard Hube and Juergen Loeffler and Oliver Kurzai},
  journal={The Journal of infectious diseases},
  year={2014},
  volume={209 4},
  pages={616-26}
}
BACKGROUND Natural killer (NK) cells are innate lymphocytes with potent cytotoxic activity. Whereas activity of NK cells has been demonstrated against the fungal pathogens Aspergillus fumigatus and Cryptococcus neoformans, little was known about their interaction with Candida albicans. METHODS Primary human NK cells were isolated from buffy coats, primed with a cytokine cocktail and used for confrontation assays with C. albicans. Interaction was monitored and quantified using live cell… CONTINUE READING