Human myoblasts modulate the function of antigen-presenting cells

@article{Schwab2008HumanMM,
  title={Human myoblasts modulate the function of antigen-presenting cells},
  author={Nicholas Schwab and Anne Waschbisch and Barbara M. Wrobel and Hanns Lochm{\"u}ller and Heinz Wiendl},
  journal={Journal of Neuroimmunology},
  year={2008},
  volume={200},
  pages={62-70}
}
Muscle biopsy specimens of myositis patients were analyzed for the presence of dendritic cells (DC) and macrophages (MPh) by immunohistochemistry. The interaction of DC and myoblasts (MB) was studied by coculture and effects on DC phenotype and function were assessed by flow cytometry and T-cell proliferation assays. Effects of MB-lysates on the phagocytic capacity of MPh were analyzed in bead-incorporation assays. Myositis specimens revealed a tendency towards more immature DC. MB modulated… CONTINUE READING
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