Human muscle metabolism during intermittent maximal exercise.

  title={Human muscle metabolism during intermittent maximal exercise.},
  author={Georgios Gaitanos and C A Will{\'i}ams and Leslie Boobis and Stephen Brooks},
  journal={Journal of applied physiology},
  volume={75 2},
Eight male subjects volunteered to take part in this study. The exercise protocol consisted of ten 6-s maximal sprints with 30 s of recovery between each sprint on a cycle ergometer. Needle biopsy samples were taken from the vastus lateralis muscle before and after the first sprint and 10 s before and immediately after the tenth sprint. The energy required to sustain the high mean power output (MPO) that was generated over the first 6-s sprint (870.0 +/- 159.2 W) was provided by an equal… 

Recovery of power output and muscle metabolites following 30 s of maximal sprint cycling in man.

The data suggest that PCr resynthesis after 30 s of maximal sprint exercise is slower than previously observed after dynamic exercise of longer duration, and PCr Resynthesis is important for the recovery of power during repeated bouts of sprint exercise.

Power output and muscle metabolism during and following recovery from 10 and 20 s of maximal sprint exercise in humans.

On two separate days eight male subjects performed a 10- or 20-s cycle ergometer sprint followed, after 2 min of recovery, by a 30-s sprint, which may be related to a reduced glycolytic ATP regeneration as a result of the higher muscle acidosis.

Contribution of phosphocreatine and aerobic metabolism to energy supply during repeated sprint exercise.

The data suggest that aerobic metabolism provides a significant part (approximately 49%) of the energy during the second sprint, whereas PCr availability is important for high power output during the initial 10 s.

Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading

The similarity of the MATCH suggests that ΔReoxy was maximal in all exercise conditions, and suggests that for intermittent sprint exercise, the metabolic O2 demands of both the respiratory and locomotor muscles can be met.

Muscle oxygenation maintained during repeated sprints despite inspiratory muscle loading

The lack of difference in ΔReoxy between INSP and CTRL suggests that for intermittent sprint exercise, the metabolic O2 demands of both the respiratory and locomotor muscles can be met.

Anaerobic Energy Supply During Maximum-Intensity Short-Term Voluntary Sustained Exercise in Man.

The purpose was to directly assess the relative contributions of the anaerobic energy releasing pathways to ATP provision during very brief (2-14s) maximal isometric contractions in human skeletal

Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation.

Seven male subjects performed repeated bouts of high-intensity exercise, on a cycle ergometer, before and after 6 d of creatine supplementation (20 g Cr H2O day-1) and there was no change in jump performance as a result of the creatine supplementation.

Neuromuscular Fatigue and Metabolism during High-Intensity Intermittent Exercise.

Findings indicate that, in endurance-trained individuals, multiple long-sprint exercise protocols induce larger impairments in performance along with greater degrees of peripheral fatigue compared to work-matched multiple short-sprints, with these differences being possibly attributed to more extensive intramuscular accumulation of lactate/H and to lower rates of glycolysis during multipleLong-Sprint exercise.

Inhaled Beta2-Agonist Increases Power Output and Glycolysis during Sprinting in Men.

The present study shows that a TER-induced increase in power output is associated with increased rates of glycogenolysis and glycolysis in skeletal muscles, and as TER counteracts a reduction in ATP in Type II fibers, TER may postpone fatigue development in these fibers.

Oxygen uptake during repeated-sprint exercise.




Muscle power and metabolism in maximal intermittent exercise.

Changes in muscle glycogen, lactate, and glycolytic intermediates suggested rate limitation at phosphofructokinase during the first and second exercise periods, and phosphorylase in the third and fourth exercise periods.

Lactate in human skeletal muscle after 10 and 30 s of supramaximal exercise.

There is evidence that pronounced lactate accumulation occurs during supramaximal exercise of a 10-s duration, suggesting that glycolysis can occur within this time frame, in contrast to the theory that glyCOlysis does not occur until endogenous phosphagen levels reach some critically low value.

A laboratory method for determination of anaerobic energy expenditure during sprinting.

  • J. M. ThomsonK. Garvie
  • Biology
    Canadian journal of applied sport sciences. Journal canadien des sciences appliquees au sport
  • 1981
Highly trained sprinters, marathon runners and untrained male control subjects were studied during treadmill sprinting to exhaustion to determine energy expenditure and demonstrate superior alactacid energy.

Effects of pH on maximal power output and fatigue during short-term dynamic exercise.

Reductions in blood pH are associated with only small reductions in the total work performed in 30 s of maximal exercise, and a delayed and smaller accumulation of lactate in plasma was observed following exercise during acidosis.

Leg muscle pH following sprint running.

Although no differences in pH and HLa were observed between the vastus lateralis and gastrocnemius muscles at the end of the treadmill trial, it is speculated that the lesser disturbance in acid-base balance seen in endurance performers may have been due to a lesser production of metabolites in their running musculature when compared to nonendurance performers.

Relationship of contraction capacity to metabolic changes during recovery from a fatiguing contraction.

The relationship between changes in muscle metabolites and the contraction capacity was investigated in humans and muscle pH was found to remain at a low level similar to that at fatigue.

Carbohydrate metabolism during hard exercise and in the recovery period after exercise.

  • E. Hultman
  • Biology
    Acta physiologica Scandinavica. Supplementum
  • 1986
Analysis of muscle tissue showed that glycogen content in muscle had decreased by 41 mmol glucosyl units X kg-1 after exercise and that 50% of this carbohydrate was retained in muscle as free glucose, phosphorylated intermediates and lactate.

Muscle metabolism during and after strenuous intermittent running.

It is concluded that exhaustive, short-term exercise activates the liver adenylate cyclase system so giving rise to an increased level of blood glucose, which is an important source of energy during this type of exercise.

Energy metabolism and contraction force of human skeletal muscle in situ during electrical stimulation.

The quadriceps femoris muscles of nine volunteers were stimulated with intramuscular electrodes for 50 s to produce an initial tension of 50‐75% of the maximum voluntary contraction force and the force declined at approximately the same rate as the ATP turnover during the contraction.

Effect of metabolic changes on force generation in skeletal muscle during maximal exercise.

During vigorous, strong contractions there is a rapid decline in the mechanical output or tension development in skeletal muscle, which is caused by metabolic changes in the muscles and is suggested that the changes in intracellular pH might affect the force generation of skeletal muscle.