Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation.

@article{Loh2016HumanMI,
  title={Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation.},
  author={Liyen Loh and Zhongfang Wang and Sneha Sant and Marios Koutsakos and Sinthujan Jegaskanda and Alexandra J Corbett and Ligong Liu and David P. Fairlie and Jane Crowe and Jamie Rossjohn and Jianqing Xu and Peter C. Doherty and James McCluskey and Katherine Kedzierska},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 36},
  pages={10133-8}
}
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory cytokines. Whether MAIT cells contribute to antiviral immunity is less clear. Here we asked whether MAIT cells produce cytokines/chemokines during severe human influenza virus infection. Our analysis in patients hospitalized with avian H7N9 influenza pneumonia showed that individuals who recovered had higher… CONTINUE READING

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