Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms

@article{Zhang2012HumanMM,
  title={Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms},
  author={Lixin Zhang and Anda M. Vlad and Christine Milcarek and Olivera Olja J Finn},
  journal={Cancer Immunology, Immunotherapy},
  year={2012},
  volume={62},
  pages={423-435}
}
MUC1 is a transmembrane mucin with important functions in normal and transformed cells, carried out by the extracellular domain or the cytoplasmic tail. A characteristic feature of the MUC1 extracellular domain is the variable number of tandem repeats (VNTR) region. Alternative splicing may regulate MUC1 expression and possibly function. We developed an RT-PCR method for efficient isolation of MUC1 mRNA isoforms that allowed us to evaluate the extent of alternative splicing of MUC1 and… CONTINUE READING
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