Human-mouse genome comparisons to locate regulatory sites

  title={Human-mouse genome comparisons to locate regulatory sites},
  author={Wyeth W. Wasserman and Michael J. Palumbo and W. R. Thompson and James W. Fickett and C. E. Lawrence},
  journal={Nature Genetics},
Elucidating the human transcriptional regulatory network is a challenge of the post-genomic era. Technical progress so far is impressive, including detailed understanding of regulatory mechanisms for at least a few genes in multicellular organisms, rapid and precise localization of regulatory regions within extensive regions of DNA by means of cross-species comparison, and de novo determination of transcription-factor binding specificities from large-scale yeast expression data. Here we address… CONTINUE READING
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