Human-mouse gene identification by comparative evidence integration and evolutionary analysis.

@article{Zhang2003HumanmouseGI,
  title={Human-mouse gene identification by comparative evidence integration and evolutionary analysis.},
  author={Lingang Zhang and Vladimir Pavlovic and Charles R. Cantor and Simon Kasif},
  journal={Genome research},
  year={2003},
  volume={13 6A},
  pages={1190-202}
}
The identification of genes in the human genome remains a challenge, as the actual predictions appear to disagree tremendously and vary dramatically on the basis of the specific gene-finding methodology used. Because the pattern of conservation in coding regions is expected to be different from intronic or intergenic regions, a comparative computational analysis can lead, in principle, to an improved computational identification of genes in the human genome by using a reference, such as mouse… CONTINUE READING

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