Human moricizine metabolism. II. Quantification and pharmacokinetics of plasma and urinary metabolites.

@article{Pieniaszek1999HumanMM,
  title={Human moricizine metabolism. II. Quantification and pharmacokinetics of plasma and urinary metabolites.},
  author={Henry J. Pieniaszek and A. G. F. Davidson and Jack E. Chaney and Linyee Shum and Clay A. Robinson and Michael Mayersohn},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1999},
  volume={29 9},
  pages={945-55}
}
1. The metabolism of moricizine.HCl was studied in 12 male volunteers dosed with 250 mg (300 microCi) 14C-radiolabelled drug. 2. Moricizine was biotransformed to many metabolites in humans (at least 35 plasma and 51 urine metabolites). 3. Urine and faecal combined mean (range) recovery accounted for 90.2% (73.4-101.6%) of the administered radioactivity, with most of the recovered radioactivity present in faeces (mean 58.4%; range 45.6-64.7%). Mean (range) urinary recovery was 31.8% (26.2-36.9… CONTINUE READING

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