Human monocytes but not dendritic cells are killed by blocking of autocrine cyclooxygenase activity.

@article{Oliveira2009HumanMB,
  title={Human monocytes but not dendritic cells are killed by blocking of autocrine cyclooxygenase activity.},
  author={Bruno de Luna Oliveira and Clara M Cavalcanti and Ana Paula Silva Azevedo and M{\'a}rcio Y Tomiyoshi and Patr{\'i}cia Cruz Bergami-Santos and Jos{\'e} Alexandre Marzag{\~a}o Barbuto},
  journal={Cellular immunology},
  year={2009},
  volume={258 1},
  pages={
          107-14
        }
}
Dendritic cells (DCs), in peripheral tissues, derive mostly from blood precursors that differentiate into DCs under the influence of the local microenvironment. Monocytes constitute the main known DC precursors in blood and their infiltration into tissues is up-regulated during inflammation. During this process, the local production of mediators, like prostaglandins (PGs), influence significantly DC differentiation and function. In the present paper we show that treatment of blood adherent… CONTINUE READING
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