Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.

@article{Briegert2007HumanMB,
  title={Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.},
  author={Manuela Briegert and Bernd Kaina},
  journal={Cancer research},
  year={2007},
  volume={67 1},
  pages={26-31}
}
Monocytes and dendritic cells are key players in the immune response. Because dendritic cells drive the tumor host defense, it is important that monocytes and dendritic cells survive cytotoxic tumor therapy. Although most of the anticancer drugs target DNA, the DNA repair capacity of monocytes and dendritic cells has not yet been investigated. We studied the sensitivity of monocytes and monocyte-derived dendritic cells against various genotoxic agents and found monocytes to be more sensitive to… CONTINUE READING
14 Extracted Citations
20 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 14 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 20 references

Similar Papers

Loading similar papers…