Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.

@article{Shah1995HumanMM,
  title={Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.},
  author={Prediman Krishan Shah and E. Falk and Juan Jose Badimon and Antonio Fern{\'a}ndez-Ort{\'i}z and Alessandra Mailhac and G Villareal-Levy and John T. Fallon and J Regnstrom and Valentin Fuster},
  journal={Circulation},
  year={1995},
  volume={92 6},
  pages={1565-9}
}
BACKGROUND Rupture of the fibrous cap of the atherosclerotic plaque is a key event that predisposes to coronary thrombosis, leading to acute coronary syndromes. Recent studies have shown that the fibrous caps of vulnerable and ruptured atherosclerotic plaques have reduced collagen and glycosaminoglycan content in association with an increased macrophage density and a reduced smooth muscle cell density. Since collagen breakdown in the fibrous caps may contribute to a thinning and weakening of… CONTINUE READING
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