Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1.

@article{Proost1996HumanMC,
  title={Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1.},
  author={Paul Proost and Anja Wuyts and Jo Van Damme},
  journal={Journal of leukocyte biology},
  year={1996},
  volume={59 1},
  pages={67-74}
}
Structurally, the monocyte chemotactic proteins MCP-1, -2, and -3 form a subfamily of the C-C or beta-chemokines. Like other chemokines, MCPs are produced by a variety of cells on stimulation with cytokines (interleukin-1, tumor necrosis factor-alpha, interferon-gamma), bacterial and viral products or mitogens. MCP-1 levels are enhanced during infection and inflammation, which are characterized by leukocyte infiltration. In vitro, MCPs are chemotactic for a distinct spectrum of target cells and… CONTINUE READING
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