Human monocyte chemoattractant protein‐1 (MCP‐1) Full‐length cDNA cloning, expression in mitogen‐stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE
@article{Yoshimura1989HumanMC, title={Human monocyte chemoattractant protein‐1 (MCP‐1) Full‐length cDNA cloning, expression in mitogen‐stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE}, author={Teizo Yoshimura and Naoya Yuhki and Stephen K. Moore and Ettore Appella and Michael I. Lerman and Edward J. Leonard}, journal={FEBS Letters}, year={1989}, volume={244} }
567 Citations
Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells.
- BiologyBiochemical and biophysical research communications
- 1997
The regulated production of MCP-2 by tumor cells and normal mesenchymal cells is indicative of a role in neoplasia and inflammatory host responses.
Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines.
- Biology, ChemistryBiochemical and biophysical research communications
- 1991
Cloning of the gene for bovine monocyte chemoattractant protein-2.
- Biology, MedicineDNA and cell biology
- 1994
An Amino acid sequence comparison of the bovine c11/1 gene product with human monocyte chemotactic proteins yielded the highest sequence identity with human MCP-2, and it is assumed that the c11-1-specific cDNA product represents the bivine M CP-2.
human monocyte chemoattractant protein-1 (MCP-1) : マウスJEのヒトhomologue
- Biology
- 1990
It is highly possible that MCP-1 is identical to JE and this protein may play an important role in macrophage infiltration in vivo.
The expression of monocyte chemotactic protein (MCP-1) in human vascular endotheliumin vitro andin vivo
- Biology, MedicineMolecular and Cellular Biochemistry
- 2005
Northern blot and slot blot analysis of RNA isolated from both the endothelium and the underlying vessel wall of freshly removed human arteries and veins showed MCP-1 transcripts, demonstrating for the first time that M CP-1 is expressed not only in atherosclerotic human arteries but also in symptom free artery and veins in vivo.
Functional role of the cis-acting elements in human monocyte chemotactic protein-1 gene in the regulation of its expression by phorbol ester in human glioblastoma cells
- BiologyMolecular and Cellular Biochemistry
- 2004
None of the MCP promoter constructs showed significant increase in CAT expression by treatment with tumor necrosis factor-α (TNF-α), which suggested that the TNF regulation of MCP-1 gene involves other parts of the gene besides the proximal 5′ flanking region.
Molecular Cloning of a Novel Human CC Chemokine Liver and Activation-regulated Chemokine (LARC) Expressed in Liver
- BiologyThe Journal of Biological Chemistry
- 1997
This chemokine was mainly expressed in liver among various tissues and strongly induced in several human cell lines by phorbol myristate acetate and may represent a new group of CC chemokines localized on chromosome 2.
Gene expression and cDNA cloning identified a major basic protein constituent of bovine seminal plasma as bovine monocyte-chemoattractant protein-1 (MCP-1).
- BiologyDNA and cell biology
- 1991
It is shown that P6 is a secretory product of the seminal vesicle tissue and monospecific anti-P6-IgGs, and Stimulation of P6 mRNA expression by phytohemagglutinin in bovine peripheral mononuclear leukocytes suggests that P 6 is identical to bovines MCP-1.
MCP‐1 is selectively expressed in the late phase by cytokine‐stimulated human neutrophils: TNF‐α plays a role in maximal MCP‐1 mRNA expression
- BiologyJournal of leukocyte biology
- 1999
Culture supernatants of phytohemagglutinin (PHA)‐stimulated human peripheral blood mononuclear cells (PHA‐sup) induced monocyte chemoattractant protein‐1 (MCP‐1) mRNA expression in human neutrophils.…
Expression of a human mutant monocyte chemotactic protein 3 in Pichia pastoris and characterization as an MCP-3 receptor antagonist.
- BiologyJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
- 1995
The cDNA encoding human monocyte chemotactic protein 3 was cloned in pHIL-S1, a vector designed for inducible secreted heterologous expression in the methylotrophic yeast Pichia pastoris to study antagonism of MCP-3 action in vitro and in disease models of cancer and inflammation.
References
SHOWING 1-10 OF 30 REFERENCES
Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties [published erratum appears in J Exp Med 1989 Dec 1;170(6):2189]
- BiologyThe Journal of experimental medicine
- 1988
In the course of studies on cachectin/TNF being conducted in the laboratory, a novel macrophage product has been detected and characterized and appears to be an endogenous mediator of the inflammatory events induced by endotoxin.
Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1987
Another proinflammatory protein is purified that is chemotactic for human neutrophils from conditioned medium of lipopolysaccharide-stimulated monocytes and has up to 56% sequence similarity with several proteins that may be involved in host responses to infection or tissue injury.
A cDNA clone used to study mRNA inducible in human tonsillar lymphocytes by a tumor promoter.
- BiologyJournal of biochemistry
- 1986
Analysis of the pLD78 cDNA sequence revealed that it codes for a polypeptide consisting of 92 amino acid residues, including a putative signal sequence, which showed a significant homology with the corresponding regions of the human interleukin 2 and immune interferon genes.
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1986
A consensus sequence, comprised entirely of A and T residues and located in the 3'-untranslated region, is conserved in toto in the murine and human TNF mRNAs, suggesting that it may serve a specific regulatory function among the m RNAs in which it is found.
Cloning and characterization of a novel T cell activation gene.
- BiologyJournal of immunology
- 1987
The combined data suggest that TCA3 may represent a new lymphokine, a T cell gene selectively expressed during activation via the antigen-receptor pathway, which is not transcribed in response to interleukin 2 stimulation, but can be detected as early as 1 hr poststimulation.
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties
- BiologyThe Journal of experimental medicine
- 1988
The identification and purification of a new inflammatory monokine synthesized by the macrophage tumor cell line RAW 264.7 suggest that MIP is an endogenous mediator that may play a role in the host responses that occur during endotoxemia and other inflammatory events.
A human T cell-specific molecule is a member of a new gene family.
- BiologyJournal of immunology
- 1988
There is significant homology between the RANTES sequence and several other T cell genes, suggesting that they comprise a previously undescribed family of small T cell molecules.
Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells
- BiologyCell
- 1985
Purification of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture.
- BiologyBiochemistry
- 1988
A dose-dependent relationship was observed between SMC-CF concentration and monocyte chemotactic activity, with maximal and half-maximal biologic activity being observed at approximately 5 and 0.1 nM, respectively.
Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1988
Structural and regulatory features of the JE gene and its product that link it to a family of cytokines, including macrophage colony-stimulating factor, interferon alpha, interleukin 6, and interLEukin 2 are presented.