Human monoclonal antibodies to SARS-coronavirus inhibit infection by different mechanisms.

@article{Coughlin2009HumanMA,
  title={Human monoclonal antibodies to SARS-coronavirus inhibit infection by different mechanisms.},
  author={Melissa M. Coughlin and John S. Babcook and Bellur S Prabhakar},
  journal={Virology},
  year={2009},
  volume={394 1},
  pages={39-46}
}
SARS-CoV causes an acute infection making targeted passive immunotherapy an attractive treatment strategy. We previously generated human mAbs specific to the S1 region of SARS-CoV S protein. These mAbs bind epitopes within the receptor binding domain (RBD) or upstream of the RBD. We show that mAbs recognizing epitopes within the RBD inhibit infection by preventing viral attachment to the cellular receptor. One mAb binds upstream of the RBD and prevents viral entry by inhibiting a post-binding… CONTINUE READING

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