Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours

@article{Ahlskog2009HumanMA,
  title={Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours},
  author={Julia K. J. Ahlskog and Christoph Schliemann and Jessica M{\aa}rlind and Uzma A Qureshi and Al-baadani Ammar and Rosamund Barbara Pedley and Dario Neri},
  journal={British Journal of Cancer},
  year={2009},
  volume={101},
  pages={645 - 657}
}
Background:Hypoxia, which is commonly observed in areas of primary tumours and of metastases, influences response to treatment. However, its characterisation has so far mainly been restricted to the ex vivo analysis of tumour sections using monoclonal antibodies specific to carbonic anhydrase IX (CA IX) or by pimonidazole staining, after the intravenous administration of this 2-nitroimidazole compound in experimental animal models.Methods:In this study, we describe the generation of high… CONTINUE READING

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