Human monoclonal antibodies produced by immortalization with Epstein-Barr virus.

Abstract

Infection with Epstein-Barr virus (EBV) triggers B lymphocytes to proliferate1, 2. B cells which carry the EBV genome can be kept indefinitely in culture while maintaining their marker characteristics, including antibody production. Unless selection pressure is applied, such immortalized cell lines produce polyclonal antibody. Virus can be used to create… (More)
DOI: 10.1016/0167-5699(81)90034-7

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Cite this paper

@article{Steinitz1981HumanMA, title={Human monoclonal antibodies produced by immortalization with Epstein-Barr virus.}, author={Michael Steinitz and E. Klein}, journal={Immunology today}, year={1981}, volume={2 2}, pages={38-9} }