Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristics.

@article{Smith2013HumanMA,
  title={Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristics.},
  author={Scott A. Smith and Ruklanthi de Alwis and Nurgun Kose and Anna Durbin and Stephen S. Whitehead and Aravinda M de Silva and James E. Crowe},
  journal={The Journal of infectious diseases},
  year={2013},
  volume={207 12},
  pages={1898-908}
}
The immunopathogenesis of severe dengue is poorly understood, but there is concern that induction of cross-reactive nonneutralizing antibodies by infection or vaccination may increase the likelihood of severe disease during a subsequent infection. We generated a total of 63 new human monoclonal antibodies to compare the B-cell response of subjects who received the National Institutes of Health live attenuated dengue vaccine rDEN1Δ30 to that of subjects following symptomatic primary infection… CONTINUE READING
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Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions

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