Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope.

@article{Thompson1991HumanMA,
  title={Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope.},
  author={Keith Michael Thompson and Joanne A. Sutherland and G A Barden and Mark D. Melamed and Ingrid Randen and Jacob B. Natvig and Virginia Pascual and J. Donald Capra and Freda K Stevenson},
  journal={Scandinavian journal of immunology},
  year={1991},
  volume={34 4},
  pages={509-18}
}
An anti-idiotypic antibody has been raised which recognizes human immunoglobulins with cold agglutinin activity of anti-I/i specificity. The pattern of reactivity of the antibody indicates that the structural basis for the epitope is located in the VH4-21 gene segment of the VHIV family, which is preferentially utilized by these cold reactive antibodies. Using this antibody, epitope expression was investigated in a panel of 72 human monoclonal allo-antibodies specific for human blood group… CONTINUE READING

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