Human monoclonal antibodies

@article{Cole2004HumanMA,
  title={Human monoclonal antibodies},
  author={S. Cole and B. Campling and T. Atlaw and D. Kozbor and J. Roder},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={62},
  pages={109-120}
}
  • S. Cole, B. Campling, +2 authors J. Roder
  • Published 2004
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • SummaryThe technology for the production of murine monoclonal antibodies has been refined enormously since its introduction in 1975. However, the technology for generating human monoclonal antibodies has only recently come into its own. In this review, three currently available approaches to the production of human monoclonal antibodies are described. These include the hybridoma technique, based on the fusion of antibody-producing human B lymphocytes with either mouse or human myeloma or… CONTINUE READING
    17 Citations

    Tables and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Human monoclonal antibodies neutralizing human cytomegalovirus.
    • 60
    Tumour-associated antigens of mammary carcinomas recognized by human monoclonal antibody 1G12
    • 1
    Advances in the production of human monoclonal antibodies
    • 20
    • PDF
    Antibody-drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids.
    • G. S. Hamilton
    • Medicine
    • Biologicals : journal of the International Association of Biological Standardization
    • 2015
    • 44
    Improving scFv stability through framework engineering

    References

    SHOWING 1-10 OF 161 REFERENCES
    The production of monoclonal antibodies from human lymphocytes.
    • 102
    Human monoclonal antibody against Forssman antigen.
    • 98
    Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.
    • L. Olsson, H. Kaplan
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1980
    • 355
    • PDF
    Generation of human monoclonal antibodies reactive with human mammary carcinoma cells.
    • 255
    • PDF
    Immunoglobulin production by a human-mouse somatic cell hybrid.
    • J. Schwaber
    • Biology, Medicine
    • Experimental cell research
    • 1975
    • 32