Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.

@article{Lan1989HumanMO,
  title={Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.},
  author={Nancy C. Y. Lan and Camilla Heinzmann and Andreas Gal and Ivana J. Klisak and Ulrike Orth and Eric J Lai and Joseph Grimsby and Robert S. Sparkes and Thuluvancheri Mohandas and Jean Chen Shih},
  journal={Genomics},
  year={1989},
  volume={4 4},
  pages={552-9}
}
Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to… CONTINUE READING

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