Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.

@article{Ban2004HumanMS,
  title={Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.},
  author={Reiko Ban and Yasuhiro Irino and Kiyoko Fukami and Hirofumi Tanaka},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 16},
  pages={
          16394-402
        }
}
Although many proteins have been shown to participate in mitotic events, including cytokinesis, their specific roles and interactions remain unclear. A novel interaction of proteins is demonstrated in this report. Yeast two-hybrid screening using PRC1 (protein-regulating cytokinesis 1) cDNA, a human mitotic spindle-associated cyclin-dependent kinase (CDK) substrate, which is involved in cytokinesis, as bait was performed. Data show that the PRC1 bait bound to MgcRacGAP, which is a GTPase… CONTINUE READING

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