Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes.

@article{Curbo2006HumanMP,
  title={Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes.},
  author={Sophie Curbo and Clotilde Lagier-Tourenne and Rosalba Carrozzo and Llu{\'i}s Palenzuela and Simona Lucioli and M Hirano and Filippo Santorelli and J. Olier Arenas and Anna Karlsson and Magnus Johansson},
  journal={Genomics},
  year={2006},
  volume={87 3},
  pages={410-6}
}
Pyrophosphatases (PPases) catalyze the hydrolysis of inorganic pyrophosphate generated in several cellular enzymatic reactions. A novel human pyrophosphatase cDNA encoding a 334-amino-acid protein approximately 60% identical to the previously identified human cytosolic PPase was cloned and characterized. The novel enzyme, named PPase-2, was enzymatically active and catalyzed hydrolysis of pyrophosphate at a rate similar to that of the previously identified PPase-1. A functional mitochondrial… CONTINUE READING