Human mitochondrial complex I assembles through the combination of evolutionary conserved modules: a framework to interpret complex I deficiencies.

@article{Ugalde2004HumanMC,
  title={Human mitochondrial complex I assembles through the combination of evolutionary conserved modules: a framework to interpret complex I deficiencies.},
  author={Cristina Ugalde and Rutger O. Vogel and Richard Huijbens and Bert van den Heuvel and Jan A.M. Smeitink and Leo G. J. Nijtmans},
  journal={Human molecular genetics},
  year={2004},
  volume={13 20},
  pages={
          2461-72
        }
}
With 46 subunits, human mitochondrial complex I is the largest enzyme of the oxidative phosphorylation system. We have studied the assembly of complex I in cultured human cells. This will provide essential information about the nature of complex I deficiencies and will enhance our understanding of mitochondrial disease mechanisms. We have found that 143B206 rho zero cells, not containing mitochondrial DNA, are still able to form complex I subcomplexes. To further address the nature of these… CONTINUE READING

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