Human mineralocorticoid receptor interacts with actin under mineralocorticoid ligand modulation

@article{Jalaguier1996HumanMR,
  title={Human mineralocorticoid receptor interacts with actin under mineralocorticoid ligand modulation},
  author={S. Jalaguier and D. Mornet and D. Mesnier and J. L{\'e}ger and G. Auzou},
  journal={FEBS Letters},
  year={1996},
  volume={384}
}
The human mineralocorticoid receptor of the steroid receptor family contains a modular structure with domain E which is considered to be a hormone binding domain. Recombinant protein approaches enabled us to clearly determine that this domain is also able to interact with F‐actin (K d about 2 μM) and G‐actin. Moreover, it was revealed that this mineralocorticoid receptor domain/actin interaction was modulated by specific mineralocorticoid ligands. Agonist (aldosterone) steroid binding almost… Expand
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