Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions.

@article{Grossmann2005HumanMR,
  title={Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions.},
  author={Claudia Ph. D. Grossmann and Andreas Benesic and Alexander W. Krug and Ruth Freudinger and Sigrid Mildenberger and Birgit Gassner and Michael Gekle},
  journal={Molecular endocrinology},
  year={2005},
  volume={19 7},
  pages={
          1697-710
        }
}
The steroid hormone aldosterone is important for salt and water homeostasis as well as for pathological tissue modifications in the cardiovascular system and the kidney. The mechanisms of action include a classical genomic pathway, but physiological relevant nongenotropic effects have also been described. Unlike for estrogens or progesterone, the mechanisms for these nongenotropic effects are not well understood, although pharmacological studies suggest a role for the mineralocorticoid receptor… CONTINUE READING
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