Human milk hyaluronan enhances innate defense of the intestinal epithelium.

  title={Human milk hyaluronan enhances innate defense of the intestinal epithelium.},
  author={David R Hill and Hyunjin K Rho and Sean P. Kessler and Ripal Amin and Craig R. Homer and Christine McDonald and Mary K. Cowman and Carol A. de la Motte},
  journal={The Journal of biological chemistry},
  volume={288 40},
Breast-feeding is associated with enhanced protection from gastrointestinal disease in infants, mediated in part by an array of bioactive glycan components in milk that act through molecular mechanisms to inhibit enteric pathogen infection. Human milk contains hyaluronan (HA), a glycosaminoglycan polymer found in virtually all mammalian tissues. We have shown that synthetic HA of a specific size range promotes expression of antimicrobial peptides in intestinal epithelium. We hypothesize that… CONTINUE READING
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