Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-X(L).

@article{Seiz2012HumanMP,
  title={Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-X(L).},
  author={Emma Gonzalez Seiz and Milagros Ramos-G{\'o}mez and Elise Th{\'e}r{\`e}se Carmen Courtois and Jan Fredrik T{\o}nnesen and Merab Kokaia and Isabel Liste Noya and Alberto Mart{\'i}nez-Serrano},
  journal={Experimental cell research},
  year={2012},
  volume={318 19},
  pages={
          2446-59
        }
}
Understanding the molecular programs of the generation of human dopaminergic neurons (DAn) from their ventral mesencephalic (VM) precursors is of key importance for basic studies, progress in cell therapy, drug screening and pharmacology in the context of Parkinson's disease. The nature of human DAn precursors in vitro is poorly understood, their properties unstable, and their availability highly limited. Here we present positive evidence that human VM precursors retaining their genuine… CONTINUE READING
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