Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells.

@article{Ulvestad1994HumanMC,
  title={Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells.},
  author={Elling Ulvestad and Kenneth Williams and Rolf Bjerkvig and Ken Tiekotter and Jack P. Antel and Roald Matre},
  journal={Journal of leukocyte biology},
  year={1994},
  volume={56 6},
  pages={732-40}
}
Resting microglia comprise up to 13% of the cells in human central nervous system (CNS) white matter. Their large number and dendritic morphology make them ideally suited to survey the CNS for noxious stimuli. Upon activation microglia gradually lose dendritic processes and transform into typical phagocytic macrophages. Microglia have been implicated as the main antigen presenting cell within the CNS, and appear to be of central importance as effectors and regulators of demyelination. To… CONTINUE READING