Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes.

@article{Sethupathy2007HumanMO,
  title={Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes.},
  author={Praveen Sethupathy and C Borel and Maryline Gagnebin and Gregory R. Grant and Samuel Deutsch and Terry S. Elton and Artemis G. Hatzigeorgiou and Stylianos E. Antonarakis},
  journal={American journal of human genetics},
  year={2007},
  volume={81 2},
  pages={
          405-13
        }
}
Animal microRNAs (miRNAs) regulate gene expression through base pairing to their targets within the 3' untranslated region (UTR) of protein-coding genes. Single-nucleotide polymorphisms (SNPs) located within such target sites can affect miRNA regulation. We mapped annotated SNPs onto a collection of experimentally supported human miRNA targets. Of the 143 experimentally supported human target sites, 9 contain 12 SNPs. We further experimentally investigated one of these target sites for hsa-miR… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 177 CITATIONS

FILTER CITATIONS BY YEAR

2004
2018

CITATION STATISTICS

  • 13 Highly Influenced Citations

  • Averaged 12 Citations per year over the last 3 years

Similar Papers

Loading similar papers…