Human miR-1271 is a miR-96 paralog with distinct non-conserved brain expression pattern

  title={Human miR-1271 is a miR-96 paralog with distinct non-conserved brain expression pattern},
  author={Kevin P. Jensen and Jonathan Covault},
  booktitle={Nucleic Acids Research},
Recent deep-sequencing efforts have identified many novel non-conserved small RNAs that are expressed at low levels in certain mammalian cells. Whether these small RNAs are important for mammalian physiology is debatable, therefore we explored the function of one such RNA, human miR-1271. This small RNA is similar in sequence to miR-96, a highly conserved microRNA that when mutated causes hearing loss in humans and mice. Although the miR-1271 and miR-96 sequences differ slightly, our in vitro… CONTINUE READING


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