Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells.

@article{Kolli2011HumanMG,
  title={Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells.},
  author={Deepthi Kolli and Xiaoyong Bao and Tianshuang Liu and Chao Hong and Tian Wang and Roberto P Garofalo and Antonella Casola},
  journal={Journal of immunology},
  year={2011},
  volume={187 1},
  pages={47-54}
}
Human metapneumovirus (hMPV) is a major cause of upper and lower respiratory infections in children and adults. Recent work from our group demonstrated that hMPV G glycoprotein is an important virulence factor, responsible for inhibiting innate immune responses in airway epithelial cells. Myeloid dendritic cells (DCs) are potent APCs and play a major role in initiating and modulating the innate and adaptive immune responses. In this study, we found that TLR4 plays a major role in hMPV-induced… CONTINUE READING

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