Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5

@article{GarcaGarca2007HumanMB,
  title={Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5},
  author={Mar{\'i}a Luz Garc{\'i}a-Garc{\'i}a and Cristina Calvo and Inmaculada Casas and Teresa Bracamonte and Alfonso Pelegr{\'i}n Rell{\'a}n and F. Gozalo and Tbs Ten{\'o}rio and Pilar Pérez-Breña},
  journal={Pediatric Pulmonology},
  year={2007},
  volume={42}
}
Human metapneumovirus (hMPV) infection plays an important role in the pediatric respiratory infections. However, little is known about the relationship between hMPV‐bronchiolitis and the development of subsequent wheezing. The aim of this study was to evaluate the outcome at third to fifth year after admission for hMPV‐bronchiolitis and to compare it with children admitted for respiratory syncytial virus (RSV)‐bronchiolitis and with children without lower respiratory disease in the first 2… Expand
Human bocavirus and metapneumovirus in acute wheezing in children—Is there a link with atopy?
TLDR
Diagnosis of bocavirus and metapneumovirus in children with a significant risk of hospital admission, risk of recurrence and subsequent asthma is improved by accessible PCR assays. Expand
Role of human metapneumovirus and respiratory syncytial virus in asthma exacerbations: where are we now?
TLDR
The prevalence of h MPV infection in pediatric and adult populations and its potential role in asthma exacerbation are discussed and recent advances made in animal models to determine immune responses following hMPV infection are reviewed. Expand
Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children
TLDR
Maternal asthma increases the risk for LTD in children <2 years old hospitalized for severe hMPV LRTI, and a potential association between h MPV and asthma also suggests that hMPVs may preferentially affect asthmatic subjects. Expand
Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children
TLDR
Outbreaks of hMPV, rather than, RSV infection may have a greater impact on the development of hypoxic respiratory illness in asthmatic children. Expand
Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China
TLDR
Phylogenetic analysis of F gene fragments indicated that three sub-genotypes of hMPV circulated in Tianjin and A2b was the predominant subtype and the Vero-E6 cell line was better than LLC-MK2 for h MPV isolation. Expand
A Comparison of Characteristics and Outcomes in Severe Human Metapneumovirus and Respiratory Syncytial Virus Infections in Children Treated in an Intensive Care Unit
TLDR
Children admitted to the PICU with HMPV are significantly older and more likely to have congenital heart disease than those with RSV, and H MPV-infected children were morelikely to be discharged with inhaled steroid therapy. Expand
Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma
TLDR
There are data to suggest children with human metapneumovirus lower respiratory tract infection may have a higher likelihood of subsequent and recurrent wheezing several years after initial infection. Expand
Human metapneumovirus in the preterm neonate: current perspectives
TLDR
HMPV is a common and important virus in premature infants, and caregivers for preterm infants should consider this virus in patients with acute respiratory symptoms, and HMPV causes nosocomial outbreaks of ARI in hospitals and long-term care facilities. Expand
Human metapneumovirus - what we know now
TLDR
This review will focus on the epidemiology, transmission, and clinical manifestations in humans as well as the animal models of HMPV pathogenesis and host immune response. Expand
Clinical and Epidemiological Comparison of Human Metapneumovirus and Respiratory Syncytial Virus in Seoul, Korea, 2003-2008
TLDR
Results show that human metapneumovirus patients exhibit several different clinical and epidemiological characteristics, such as higher proportion of wheezing illness, age and seasonal incidence, and eosinophil counts, when compared to RSV patients. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
Presence of the new human metapneumovirus in French children with bronchiolitis
We developed a polymerase chain reaction (PCR) to detect human metapneumovirus (hMPV) in French children hospitalized for acute respiratory tract disease during the winter of 2001 to 2002. This assayExpand
Human Metapneumovirus and Respiratory Syncytial Virus, Brazil
We describe the epidemiologic and clinical characteristics of 111 children attending clinics and hospitals in Aracaju, northeast Brazil, with acute respiratory infections attributable to humanExpand
Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong
TLDR
Human metapneumovirus (HMPV) is a newly discovered pathogen thought to be associated with respiratory disease and was associated with clinical diagnoses of pneumonia, asthma exacerbation, or acute bronchiolitis over a 13-month period in Hong Kong. Expand
Human metapneumovirus as a causative agent of acute bronchiolitis in infants
TLDR
It is suggested that hMPV is a common and important causative agent in infants with bronchiolitis, with clinical characteristics similar to that of RSV. Expand
Metapneumovirus and acute wheezing in children
TLDR
Human metapneumovirus is a clinically important causative agent of acute wheezing in young children and regulated upon activation. Expand
Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7.
TLDR
RSV bronchiolitis in infancy severe enough to cause hospitalization was highly associatied with the development of asthma and allergic sensitization up to age 7(1)/ (2). Expand
Human metapneumovirus infection in children hospitalized for wheezing
TLDR
The study was an observational, case-control study of 133 children hospitalized for wheezing between April 1, 2000, and March 31, 2001, and the prevalence of positive tests for hMPV among children <3 years old was 8.9%. Expand
Human metapneumovirus infections in hospitalised infants in Spain
TLDR
Human metapneumovirus was the second most frequent virus after RSV in infants <2 years of age hospitalised for respiratory infection and was associated with lower respiratory tract infections. Expand
Human metapneumovirus and respiratory syncytial virus in hospitalized danish children with acute respiratory tract infection
TLDR
HMPV is present in young Danish children hospitalized with ARTI although less frequent than RSV and with a tendency to a milder clinical course, but more RSV-infected children required respiratory support. Expand
Prospective Study of Human Metapneumovirus Infection in Children Less Than 3 Years of Age
TLDR
The hypothesis that coinfections with RSV and h MPV are more severe than infections with either RSV or hMPV alone, at least in children younger than 3 years of age is supported. Expand
...
1
2
3
4
5
...