Human metabolism of tolfenamic acid. I. Isolation, preliminary characterization and pharmacokinetics of tolfenamic acid and its metabolites

The metabolic fate and pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent, was studied after intravenous and oral administration of14C-tolfenamic acid to one healthy volunteer. The recovery in urine was 77% of the intravenous dose and 93% of the oral dose. About 11% of the doses was found in faeces after both routes of administration whereas… CONTINUE READING