Human metabolism of the experimental cancer therapeutic agentd-limonene

  title={Human metabolism of the experimental cancer therapeutic agentd-limonene},
  author={Pamela Crowell and Charles E. Elson and Howard H. Bailey and Abiodun Elegbede and Jill D. Haag and Michael N. Gould},
  journal={Cancer Chemotherapy and Pharmacology},
d-Limonene has efficacy in preclinical models of breast cancer, causing >80% of carcinomas to regress with little host toxicity. We performed a pilot study on healthy human volunteers to identify plasma metabolites of limonene and to assess the toxicity of supradietary quantities ofd-limonene. Seven subjects ingested 100 mg/kg limonene in a custard. Blood was drawn at 0 and 24 h for chemistry-panel analysis and at 0, 4, and 24 h for limonenemetabolite analysis. On-line capillary gas… CONTINUE READING
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Studies on the metabolism of d-limonene (p-mentha-l,8-diene). IV. Isolation and characterization of new metabolites and species differences in metabolism

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Highly Influential
7 Excerpts

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1 Excerpt

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