Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity.

@article{Bocchetta2000HumanMC,
  title={Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity.},
  author={Maurizio Bocchetta and I Di Resta and Amy C. Powers and Raoul Fresco and Alessandra Tosolini and Joseph R Testa and Harvey I. Pass and Paola Rizzo and Michele Carbone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 18},
  pages={10214-9}
}
Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different from the semipermissive infection thought to be characteristic of human cells. Mesothelial cells are uniformly infected but not lysed by SV40, a mechanism related to p53, and undergo cell transformation at an extremely high rate. Exposure of mesothelial cells to asbestos complemented SV40 mutants in transformation… CONTINUE READING