Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.

@article{Chan2016HumanMS,
  title={Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.},
  author={Michael Chi Wai Chan and Denise I. T. Kuok and Connie Leung and Kenrie Pui-Yan Hui and Sophie Alessandra Valkenburg and Eric H. Y. Lau and John Malcolm Nicholls and Xiaohui Fang and Yi Guan and Jae-Woo Lee and Renee W. Y. Chan and Robert James Webster and Michael A. Matthay and Joseph Sriyal Malik Peiris},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 13},
  pages={
          3621-6
        }
}
Influenza can cause acute lung injury. Because immune responses often play a role, antivirals may not ensure a successful outcome. To identify pathogenic mechanisms and potential adjunctive therapeutic options, we compared the extent to which avian influenza A/H5N1 virus and seasonal influenza A/H1N1 virus impair alveolar fluid clearance and protein permeability in an in vitro model of acute lung injury, defined the role of virus-induced soluble mediators in these injury effects, and… CONTINUE READING
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