Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat.

@article{Devaney2015HumanMS,
  title={Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat.},
  author={James J Devaney and Shahd Horie and Claire Masterson and Steve J. Elliman and F Barry and Timothy O'Brien and Gerard F Curley and Daniel O'Toole and John G. Laffey},
  journal={Thorax},
  year={2015},
  volume={70 7},
  pages={625-35}
}
BACKGROUND Mesenchymal stromal cells (MSCs) demonstrate considerable promise in preclinical acute respiratory distress syndrome models. We wished to determine the efficacy and mechanisms of action of human MSCs (hMSCs) in the setting of acute lung injury induced by prolonged Escherichia coli pneumonia in the rat. METHODS Adult male Sprague Dawley rats underwent intratracheal instillation of E. coli bacteria in all experiments. In Series 1, animals were randomised to intravenous administration… CONTINUE READING