Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming

@inproceedings{Selleri2016HumanMS,
  title={Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming},
  author={Silvia Selleri and Panojot Bifsha and Sara Civini and Consiglia Pacelli and Mame Massar Dieng and William Lemieux and Ping Jin and Ren{\'e}e Bazin and Natacha Patey and Francesco M. Marincola and Florina Moldovan and Charlotte Zaouter and L. C. Trudeau and Basma Benabdhalla and Isabelle Louis and Christian M. Beaus{\'e}jour and David F Stroncek and Françoise le Deist and Elie Haddad},
  booktitle={Oncotarget},
  year={2016}
}
Human mesenchymal stromal cells (MSC) have been shown to dampen immune response and promote tissue repair, but the underlying mechanisms are still under investigation. Herein, we demonstrate that umbilical cord-derived MSC (UC-MSC) alter the phenotype and function of monocyte-derived dendritic cells (DC) through lactate-mediated metabolic reprogramming. UC-MSC can secrete large quantities of lactate and, when present during monocyte-to-DC differentiation, induce instead the acquisition of M2… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 75 references

Similar Papers

Loading similar papers…