Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes.

@article{HofNahor2012HumanMS,
  title={Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes.},
  author={Irit Hof-Nahor and Lucy Leshansky and Shoham Shivtiel and Liron Eldor and Daniel Aberdam and Joseph Itskovitz-Eldor and Sonia Berrih-Aknin},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 19},
  pages={4640-50}
}
The mechanisms underlying the immunomodulatory effects of mesenchymal stem cells (MSCs) have been investigated under extreme conditions of strong T cell activation, which induces the rapid death of activated lymphocytes. The objective of this study was to investigate these mechanisms in the absence of additional polyclonal activation. In co-cultures of peripheral mononuclear blood cells with human MSCs (hereafter referred to as hMSCs), we observed a striking decrease in the level of CD8… CONTINUE READING

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