Human mesenchymal stem cells play a dual role on tumor cell growth in vitro and in vivo.

  title={Human mesenchymal stem cells play a dual role on tumor cell growth in vitro and in vivo.},
  author={Lin Li Hui Tian and Weiming Yue and Feng Zhu and Shuhai Li and Wenjun Li},
  journal={Journal of cellular physiology},
  volume={226 7},
Nowadays, some evidences demonstrate that human mesenchymal stem cells (hMSCs) favor tumor growth; however, others show that hMSCs can suppress tumorigenesis and tumor growth. With the indeterminateness of the effect of hMSCs on tumors, we investigated the effect of hMSCs on lung cancer cell line A549 and esophageal cancer cell line Eca-109 in vitro and in vivo. Our results revealed that hMSCs inhibited the proliferation and invasion of A549 and Eca-109 cells, arrested tumor cells in the G1… CONTINUE READING
50 Citations
30 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 50 extracted citations


Publications referenced by this paper.
Showing 1-10 of 30 references

Bonemarrow - derived cells and tumor growth : Contribution of bone marrow - derived cells to tumor micro - environments with special focus on mesenchymal stem cells

  • BD Roorda, A terElst, KampsWA, ES deBont
  • Crit Rev Oncol Hematol
  • 2009
Highly Influential
5 Excerpts

Mesenchymal stem cells derived fromCD 133 - positive cells in mobilized peripheral blood and cord blood : Proliferation , Oct 4 expression , and plasticity

  • AH Undale, JJ Westendorf, MJ Yaszemski, S Khosla
  • 2009
1 Excerpt

Toll - like receptors on human mesenchymal

  • SL Tomchuck, ZwezdarykKJ, SB Coffelt, WatermanRS, ScandurroAB Danka ES
  • stem cells
  • 2008
1 Excerpt

Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells : Impact on in vivo tumor growth

  • RamasamyR, Lam EW-F, I Soeiro, V Tisato, BonnetD, F Dazzi
  • Leukemia
  • 2007

Similar Papers

Loading similar papers…