Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves.

@article{Batten2006HumanMS,
  title={Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves.},
  author={Puspa Batten and Padmini Sarathchandra and Joseph W. Antoniw and Szun Szun Tay and Mark W. Lowdell and Patricia M. Taylor and Magdi Habib Yacoub},
  journal={Tissue engineering},
  year={2006},
  volume={12 8},
  pages={2263-73}
}
To generate an ''off the shelf'' tissue-engineered heart valve, the cells would need to be of allogeneic origin. Here, we report the possibility of using human bone marrow-derived mesenchymal stem cells (MSCs) as a suitable allogeneic cell source for tissue-engineered heart valves. Proliferative responses of primary and primed CD4+ T cells to allogeneic MSCs were examined. A protein microarray system was used to detect soluble factors from supernatants collected from the T cell assays. MSCs are… CONTINUE READING