Human mesenchymal stem cells differentiate into keratocyte-like cells in keratocyte-conditioned medium.

@article{Park2012HumanMS,
  title={Human mesenchymal stem cells differentiate into keratocyte-like cells in keratocyte-conditioned medium.},
  author={Soo Hyun Park and Kyoung Woo Kim and Yeoun Sook Chun and Jae Chan Kim},
  journal={Experimental eye research},
  year={2012},
  volume={101},
  pages={16-26}
}
Culturing corneal keratocytes is difficult because keratocytes growing in a monolayer rapidly lose their stellate morphology and cease to express keratocyte markers such as keratocan, lumican and aldehyde dehydrogenase 1 family, member A1 (ALDH1A1). Conversely, mesenchymal stem cells (MSCs) can be easily expanded in cell culture, and they have a variety of differentiation pathways. We studied the feasibility of using MSCs as a source for corneal tissue engineering. Based on the observation that… CONTINUE READING
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