Human mesenchymal stem cells cultured on silk hydrogels with variable stiffness and growth factor differentiate into mature smooth muscle cell phenotype.

@article{Floren2016HumanMS,
  title={Human mesenchymal stem cells cultured on silk hydrogels with variable stiffness and growth factor differentiate into mature smooth muscle cell phenotype.},
  author={Michael L Floren and Walter Bonani and Anirudh Dharmarajan and Antonella Motta and Claudio Migliaresi and Wei Tan},
  journal={Acta biomaterialia},
  year={2016},
  volume={31},
  pages={156-166}
}
UNLABELLED Cell-matrix and cell-biomolecule interactions play critical roles in a diversity of biological events including cell adhesion, growth, differentiation, and apoptosis. Evidence suggests that a concise crosstalk of these environmental factors may be required to direct stem cell differentiation toward matured cell type and function. However, the culmination of these complex interactions to direct stem cells into highly specific phenotypes in vitro is still widely unknown, particularly… CONTINUE READING

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