Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis.

@article{Crigler2006HumanMS,
  title={Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis.},
  author={Lauren Crigler and Rebecca Caroline Robey and Amy Asawachaicharn and Dina Gaupp and Donald G Phinney},
  journal={Experimental neurology},
  year={2006},
  volume={198 1},
  pages={54-64}
}
Mesenchymal stem cells (MSCs) transplanted at sites of nerve injury are thought to promote functional recovery by producing trophic factors that induce survival and regeneration of host neurons. To evaluate this phenomenon further, we quantified in human MSCs neurotrophin expression levels and their effects on neuronal cell survival and neuritogenesis. Screening a human MSC cDNA library revealed expressed transcripts encoding BDNF and beta-NGF but not NT-3 and NT-4. Immunostaining demonstrated… CONTINUE READING
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