Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy

@inproceedings{Estrada2013HumanMS,
  title={Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy},
  author={Juan Camilo Estrada and Yuselis Torres and Alberto Bengur{\'i}a and Ana Dopazo and Enrico Roche and L Carrera-Quintanar and Raquel P{\'e}rez and J A Enr{\'i}quez and R Torres and J C Ram{\'i}rez and Enrique Samper and Antonio Bernad},
  booktitle={Cell Death and Disease},
  year={2013}
}
In most clinical trials, human mesenchymal stem cells (hMSCs) are expanded in vitro before implantation. The genetic stability of human stem cells is critical for their clinical use. However, the relationship between stem-cell expansion and genetic stability is poorly understood. Here, we demonstrate that within the normal expansion period, hMSC cultures show a high percentage of aneuploid cells that progressively increases until senescence. Despite this accumulation, we show that in a… CONTINUE READING
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